1,3-Dibromo-2-propanol → 1,3-Bis(benzylthio)-2-propanol

HRID 259273노트

반응식

HRID 259273 반응식
Br[CH2:2][CH:3]([OH:6])[CH2:4]Br.[CH2:7]([SH:14])[C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1.[H-].[Na+]>O1CCCC1>[CH2:7]([S:14][CH2:2][CH:3]([OH:6])[CH2:4][S:14][CH2:7][C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1)[C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1

참가 물질

5

반응물 3

HCID 72871,3-Dibromo-2-propanolHCID 7509Benzyl mercaptanHCID 24758Sodium hydride

생성물 1

HCID 158896411,3-Bis(benzylthio)-2-propanol

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

1,3-dibromo-2-propanol (2.18 g.) is added to a stirred suspension of the salt obtained by mixing 2.7 g. benzyl mercaptan and sodium hydride (56% dispersion in mineral oil; 900 mg.) in 50 ml. dry tetrahydrofuran. After 2 hours at room temperature, the solvent is removed and 20 ml. of water is added to the residue. The resultant aqueous mixture is extracted with ether and the extracts washed with water, dried over magnesium sulfate and evaporated to yield 1,3-bis(benzylthio)-2-propanol.

후처리

  1. customobtained
  2. additionby mixing 2.7 g
  3. customthe solvent is removed
  4. additionof water is added to the residue
  5. extractionThe resultant aqueous mixture is extracted with ether
  6. washthe extracts washed with water
  7. dry with materialdried over magnesium sulfate
  8. customevaporated

출처 및 근거

ORD 기록
ord-536ea60cb1c54306a8415c4d5b8a0e4e
출처 데이터셋
uspto-grants-1977_07
특허 번호
US04036970

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