Trimethyl orthoformate → 4-(2-Carboxyethenyl)benzoic acid

HRID 259433노트

반응식

HRID 259433 반응식
[CH:1]([C:3]1[CH:13]=[CH:12][C:6]([CH:7]=[CH:8][C:9]([OH:11])=[O:10])=[CH:5][CH:4]=1)=[O:2].C(OC)(OC)[O:15]C>CO>[C:1]([C:3]1[CH:13]=[CH:12][C:6]([CH:7]=[CH:8][C:9]([OH:11])=[O:10])=[CH:5][CH:4]=1)([OH:15])=[O:2]

참가 물질

4

반응물 2

HCID 9005Trimethyl orthoformateHCID 980772-Propenoic acid, 3-(4-formylphenyl)-

생성물 1

HCID 891964-(2-Carboxyethenyl)benzoic acid

시약·촉매·용매 1

HCID 887Methanol용매2회

실험 절차

A solution of 37.0 g of 4-formylcinnamic acid in 22 ml of trimethyl orthoformate and 600 ml of methanol was heated under reflux for 17 hrs. with stirring. At the end of this time, 100 ml of methanol was added and the reaction mixture was heated under reflux for an additional 5 hrs. and then allowed to cool to room temperature. The precipitate was collected, washed with methanol and dried at 75°-80° overnight to give 7.36 g of 4-carboxycinnamic acid.

후처리

  1. temperatureunder reflux for 17 hrs
  2. temperaturethe reaction mixture was heated
  3. temperatureunder reflux for an additional 5 hrs
  4. customThe precipitate was collected
  5. washwashed with methanol
  6. customdried at 75°-80° overnight

출처 및 근거

ORD 기록
ord-081276a15ba547f89388c4ebbb1a2408
출처 데이터셋
uspto-grants-1977_07
특허 번호
US04038289

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