Pyridine → 3-Benzoylamino-5-nitro-2-pyridone

HRID 259551노트

반응식

HRID 259551 반응식
[NH2:1][C:2]1[C:3](=[O:11])[NH:4][CH:5]=[C:6]([N+:8]([O-:10])=[O:9])[CH:7]=1.N1C=CC=CC=1.[C:18](Cl)(=[O:25])[C:19]1[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=1>O>[C:18]([NH:1][C:2]1[C:3](=[O:11])[NH:4][CH:5]=[C:6]([N+:8]([O-:10])=[O:9])[CH:7]=1)(=[O:25])[C:19]1[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=1

참가 물질

5

반응물 3

HCID 1049PyridineHCID 7412Benzoyl chlorideHCID 227547823-Amino-5-nitropyridin-2(1H)-one

생성물 1

HCID 227547673-Benzoylamino-5-nitro-2-pyridone

시약·촉매·용매 1

HCID 962Water용매

실험 절차

A solution of 100 mg. of 3-amino-5-nitro-2-pyridone in 1.5 ml. of pyridine was cooled and treated with 200 mg. of benzoyl chloride. After 2 hours water was added. The oil that separated was washed with water and triturated with ether. The resultant solid was recrystallized from ethyl acetate to give 3-benzoylamino-5-nitro-2-pyridone, m.p. 267°-268° C.

후처리

  1. additiontreated with 200 mg
  2. customThe oil that separated
  3. washwas washed with water
  4. customtriturated with ether
  5. customThe resultant solid was recrystallized from ethyl acetate

출처 및 근거

ORD 기록
ord-079b0e23338641ffac98174dfa2c9a3f
출처 데이터셋
uspto-grants-1977_07
특허 번호
US04038396

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