Methyl 2-chloroacetoacetate → Methyl 3-amino-2-chloro-2-butenoate

HRID 259801

반응식

HRID 259801 반응식
[Cl:1][CH:2]([C:7]([CH3:9])=O)[C:3]([O:5][CH3:6])=[O:4].C([O-])(=O)C.[NH4+:14]>CO>[NH2:14][C:7]([CH3:9])=[C:2]([Cl:1])[C:3]([O:5][CH3:6])=[O:4]

참가 물질

4

반응물 2

HCID 107332Methyl 2-chloroacetoacetateHCID 517165Ammonium Acetate

생성물 1

HCID 76224675Methyl 3-amino-2-chloro-2-butenoate수율 63.9%

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

50 g (0.33 mol) of methyl 2-chloroacetoacetate are reacted with 64 g (0.83 mol) of ammonium acetate in 100 ml of methanol and worked up in analogy to Example 2. Yield: 63.9% [GC]

출처 및 근거

ORD 기록
ord-a4e4aeabb417434fb462652a54b6fdbb
출처 데이터셋
uspto-grants-1996_06
특허 번호
US05523404

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