(1H-indol-2-yl)methanol → Indole-2-carboxaldehyde

HRID 259823

반응식

HRID 259823 반응식
[NH:1]1[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[CH:3]=[C:2]1[CH2:10][OH:11]>C(Cl)Cl.O=[Mn]=O>[CH:10]([C:2]1[NH:1][C:9]2[C:4]([CH:3]=1)=[CH:5][CH:6]=[CH:7][CH:8]=2)=[O:11]

참가 물질

4

반응물 1

HCID 98783(1H-indol-2-yl)methanol

생성물 1

HCID 96389Indole-2-carboxaldehyde

시약·촉매·용매 2

HCID 14801Manganese dioxide촉매HCID 6344Dichloromethane용매

실험 절차

A total of 1.76 g of 2-indolemethanol was dissolved in dry CH2Cl2 (20 mL) at room temperature and stirred overnight with MnO2 (2.1 g, 24 mmol). The mixture was filtered through Celite, the filtrate was evaporated under reduced pressure, and the product was purified by flash chromatography (CH2Cl2). Yield: 1.31 g (75%), 1H NMR (CDCl3): δ7.1-7.5 (m, 4H), 7.76 (d, 1H, J=7.8 Hz), 9.41 (br s, 1H), 9.86 (s, 1H).MS EI): m/z 145 (M+).

후처리

  1. filtrationThe mixture was filtered through Celite
  2. customthe filtrate was evaporated under reduced pressure
  3. customthe product was purified by flash chromatography (CH2Cl2)

출처 및 근거

ORD 기록
ord-60ef377f2f62446ba45f801c0bb4075c
출처 데이터셋
uspto-grants-1996_06
특허 번호
US05523411

연결된 노트

불러오는 중…