Trioctylamine → Methyl 2,3,4,5-tetrafluorobenzoate

반응식

[CH3:1][O:2][C:3](=[O:17])[C:4]1[C:5](=[C:9]([F:16])[C:10]([F:15])=[C:11]([F:14])[C:12]=1[F:13])C(O)=O.C(N(CCCCCCCC)CCCCCCCC)CCCCCCC>>[CH3:1][O:2][C:3](=[O:17])[C:4]1[CH:5]=[C:9]([F:16])[C:10]([F:15])=[C:11]([F:14])[C:12]=1[F:13]

참가 물질

반응물 2

HCID 14227Trioctylamine

HCID 108579443,4,5,6-Tetrafluorophthalic acid-monomethyl ester

생성물 1

HCID 600996Methyl 2,3,4,5-tetrafluorobenzoate수율 86.4%

반응 조건

온도: 140 °C

실험 절차

Into a 100 ml three necked flask, 20 g (0.079 mol) of the 3,4,5,6-tetrafluorophthalic acid-monomethyl ester prepared in Example 14, and 2.8 g (0.0079 mol) of tri-n-octylamine were charged, and the mixture was heated and stirred at 140° C. for 24 hours. After completion of the reaction, the reaction mixture was separated by distillation to obtain 14.2 g of 2,3,4,5tetrafluorobenzoic acid methyl ester. The yield was 86.3%.

후처리

temperaturethe mixture was heated
customAfter completion of the reaction
customthe reaction mixture was separated by distillation

출처 및 근거

ORD 기록: ord-e72bc0d2a4474c13ae3b233e513741cc
출처 데이터셋: uspto-grants-1996_06
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US05523476

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