Diethyl Ether → 2,2-Dimethylhexan-1-amine

HRID 26008

반응식

HRID 26008 반응식
[CH3:1][C:2]([CH3:9])([CH2:5][CH2:6][CH2:7][CH3:8])[C:3]#[N:4].CCOCC.[H-].[Al+3].[Li+].[H-].[H-].[H-].[OH-].[Na+]>O>[CH3:1][C:2]([CH3:9])([CH2:5][CH2:6][CH2:7][CH3:8])[CH2:3][NH2:4]

참가 물질

6

반응물 4

HCID 3283Diethyl Ether2회HCID 14798Sodium HydroxideHCID 35735622,2-DimethylhexanenitrileHCID 21226445Aluminium lithium hydride

생성물 1

HCID 543253312,2-Dimethylhexan-1-amine

시약·촉매·용매 1

HCID 962Water용매2회

실험 절차

A solution of 2,2-dimethylcapronitrile (10.0 g., 0.078 mole) in 100 ml. of ether is added slowly to a suspension of lithium aluminum hydride (6.0 g., 0.158 mole) in 200 ml. of ether while maintaining the reaction at 0°-5°. After stirring the reaction mixture for an additional 2 hr., at 0.5°, the mixture is hydrolyzed by sequentially adding 6.0 ml. of water, 6.0 ml. of 15% sodium hydroxide solution, and finally 18 ml. of water. The hydrolyzed mixture is stirred for an additional hour, filtered and the ether phase concentrated under reduced pressure. Distillation of residual material provides 2,2-dimethylhex-1-ylamine.

후처리

  1. customthe reaction at 0°-5°
  2. customat 0.5°
  3. additionby sequentially adding 6.0 ml
  4. stirringThe hydrolyzed mixture is stirred for an additional hour
  5. filtrationfiltered
  6. concentrationthe ether phase concentrated under reduced pressure
  7. distillationDistillation of residual material

출처 및 근거

ORD 기록
ord-eeed12b3af744259bd76c2d7e4263f32
출처 데이터셋
uspto-grants-1979_04
특허 번호
US04147805

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