Dimethylthiocarbamoyl chloride → Dimethylthiocarbamoyl valine

HRID 260133

반응식

HRID 260133 반응식
C([O:3][C:4](=[O:10])[C@H:5]([CH:7]([CH3:9])[CH3:8])[NH2:6])C.[CH3:11][N:12]([CH3:16])[C:13](Cl)=[S:14]>C(#N)C>[CH3:11][N:12]([CH3:16])[C:13]([NH:6][C@H:5]([C:4]([OH:3])=[O:10])[CH:7]([CH3:9])[CH3:8])=[S:14]

참가 물질

4

반응물 2

HCID 27871Dimethylthiocarbamoyl chlorideHCID 87182l-Valine, ethyl ester

생성물 1

HCID 53885838Dimethylthiocarbamoyl valine

시약·촉매·용매 1

HCID 6342Acetonitrile용매

실험 절차

Valine ethyl ester (0.0028 mol) in 10 ml acetonitrile was reacted with dimethylthiocarbamoyl chloride (0.0056 mol) at 50° C. for 2 hours. Solvent acetonitrile was removed by rotary evaporation. Trifluoroacetic acid (10 ml) was added and the mixture stirred at room temperature for 15 min. The trifluoroacetic acid was removed by rotary evaporation. The residue was dissolved in water and analyzed by FAB/MS. The expected product, dimethylthiocarbamoyl valine (MH+=205), was obtained.

후처리

  1. customSolvent acetonitrile was removed by rotary evaporation
  2. additionTrifluoroacetic acid (10 ml) was added
  3. customThe trifluoroacetic acid was removed by rotary evaporation
  4. dissolutionThe residue was dissolved in water

출처 및 근거

ORD 기록
ord-7c3f4ac9582a492d88c902c8d1fa939d
출처 데이터셋
uspto-grants-1996_06
특허 번호
US05525707

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