Water → 4-Aminocoumarin

HRID 26037

반응식

HRID 26037 반응식
O[C:2]1[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[O:5][C:4](=[O:12])[CH:3]=1.C([O-])(=O)C.[NH4+:17].O>C(O)CO>[NH2:17][C:2]1[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[O:5][C:4](=[O:12])[CH:3]=1

참가 물질

5

반응물 3

HCID 962WaterHCID 517165Ammonium AcetateHCID 546829304-Hydroxycoumarin

생성물 1

HCID 8208074-Aminocoumarin수율 99.4%

시약·촉매·용매 1

HCID 174Ethylene Glycol용매

반응 조건

온도
60 °C

실험 절차

97.2 g of 4-hydroxycoumarin and 69.3 g of ammonium acetate in 300 ml of ethylene glycol are heated to 70° C. for 3 hours, whilst stirring, and to 160° C. for 6 hours, the mixture is cooled to 60° C., 1 liter of water is added, whilst stirring, and the mixture is cooled to room temperature. The colourless crystalline precipitate is filtered off, washed with water and dried in vacuo at 60° C. 96 g of 4-aminocoumarin in an almost pure form are obtained

후처리

  1. stirringwhilst stirring
  2. temperaturethe mixture is cooled to room temperature
  3. filtrationThe colourless crystalline precipitate is filtered off
  4. washwashed with water
  5. customdried in vacuo at 60° C

출처 및 근거

ORD 기록
ord-6c8bd853f10e4d0da1191df774022583
출처 데이터셋
uspto-grants-1979_04
특허 번호
US04147865

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