Sodium cyanoborohydride → HCID 54173271, 화합물

HRID 260546노트

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HRID 260546 반응식
[NH2:1][CH:2]([C:6]#[N:7])[C:3]([OH:5])=[O:4].[CH3:8][C:9]1C=CC(S(OCC)(=O)=O)=CC=1.[CH3:21][N:22]([CH:24]=[N:25][S:26]([C:29]1[C:30]([C:35]2[CH:40]=[CH:39][C:38]([CH:41]=O)=[CH:37][CH:36]=2)=[CH:31][CH:32]=[CH:33][CH:34]=1)(=[O:28])=[O:27])[CH3:23].C([BH3-])#N.[Na+]>ClCCl>[C:6]([CH:2]([NH:1][CH2:41][C:38]1[CH:39]=[CH:40][C:35]([C:30]2[CH:31]=[CH:32][CH:33]=[CH:34][C:29]=2[S:26]([N:25]=[CH:24][N:22]([CH3:23])[CH3:21])(=[O:28])=[O:27])=[CH:36][CH:37]=1)[C:3]([O:5][CH2:8][CH3:9])=[O:4])#[N:7]

참가 물질

5

반응물 3

HCID 5003444Sodium cyanoborohydrideHCID 54273713N'-(4'-Formyl[1,1'-biphenyl]-2-sulfonyl)-N,N-dimethylmethanimidamideHCID 86749579HCID 86749579, 화합물

생성물 1

HCID 54173271HCID 54173271, 화합물수율 29.9%

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

2 g of ethyl mono (4-methylbenzenesulfonate) aminocyano acetate of Stage B of Example 1 and 1.9 g of N-[(dimethylamino) methylene]-4'-formyl-(1,1'-biphenyl)-2-sulfonamide of Stage A of Example 1 were stirred in dichloromethane at 35° for 3 hours and then 0.396 g of sodium cyano borohydride were added. The solution was stirred at ambient temperature for 18 hours and the reaction mixture was filtered, washed with water and evaporated. After chromatography on silica (dichloromethane-ethyl acetate 85-15), 770 mg of the expected product were obtained, identical to that of Stage C of Example 1.

후처리

  1. filtrationthe reaction mixture was filtered
  2. washwashed with water
  3. customevaporated

출처 및 근거

ORD 기록
ord-103d0109561a4abead21deeda985d7ac
출처 데이터셋
uspto-grants-1996_06
특허 번호
US05527919

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