Acetic Anhydride → 1-Acetamido-7-naphthol

HRID 260667

반응식

HRID 260667 반응식
[NH2:1][C:2]1[CH:3]=[CH:4][CH:5]=[C:6]2[C:11]=1[CH:10]=[C:9]([OH:12])[CH:8]=[CH:7]2.[C:13](OC(=O)C)(=[O:15])[CH3:14]>>[OH:12][C:9]1[CH:10]=[C:11]2[C:6]([CH:5]=[CH:4][CH:3]=[C:2]2[NH:1][C:13](=[O:15])[CH3:14])=[CH:7][CH:8]=1

참가 물질

3

반응물 2

HCID 7918Acetic AnhydrideHCID 83588-Amino-2-naphthalenol

생성물 1

HCID 809461-Acetamido-7-naphthol수율 98.3%

실험 절차

100 g (0.55 mol) of 8-aminonaphth-2-ol are poured into 125 ml (135.25 g or 1.325 mol) of acetic anhydride cooled in an ice bath, and the mixture is stirred under cold conditions for 1 h. The mixture obtained is poured into 375 ml of ice-water and stirred for several hours. The violet solid is collected by filtration, washed three times with 30 ml of diethyl ether and dried under reduced pressure. 108.8 g of a product melting point: 193°-195° C. are obtained which is used as it is in the following step.

후처리

  1. temperaturecooled in an ice bath
  2. customThe mixture obtained
  3. stirringstirred for several hours
  4. filtrationThe violet solid is collected by filtration
  5. washwashed three times with 30 ml of diethyl ether
  6. customdried under reduced pressure

출처 및 근거

ORD 기록
ord-13936575bfc34ea29975b969b0f98d9f
출처 데이터셋
uspto-grants-1996_06
특허 번호
US05530002

연결된 노트

불러오는 중…