Benzyl Alcohol → Benzyl 6-Bromohexyl Ether

HRID 260820노트

반응식

HRID 260820 반응식
[H-].[Na+].[CH2:3]([OH:10])[C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][CH:5]=1.[Br:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17]Br>O1CCOCC1>[Br:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][O:10][CH2:3][C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][CH:5]=1

참가 물질

5

반응물 3

HCID 244Benzyl AlcoholHCID 123681,6-DibromohexaneHCID 24758Sodium hydride

생성물 1

HCID 2784764Benzyl 6-Bromohexyl Ether

시약·촉매·용매 1

HCID 312751,4-Dioxane용매3회

실험 절차

To a suspension of sodium hydride in 1,4-dioxane was added benzyl alcohol in 1,4-dioxane over a period of 30 minutes at 80° C., and the mixture was stirred for 1 hour. The obtained alkoxide solution was added to a solution of 1,6-dibromohexane in 1,4-dioxane at room temperature. The mixture was stirred at 80° C. for 14 hours and insoluble materials were filtered off. The filtrate was concentrated and the residue was distilled under reduced pressure to give the object compound.

후처리

  1. stirringThe mixture was stirred at 80° C. for 14 hours
  2. filtrationinsoluble materials were filtered off
  3. concentrationThe filtrate was concentrated
  4. distillationthe residue was distilled under reduced pressure
  5. customto give the object compound

출처 및 근거

ORD 기록
ord-9d1d155b2a884e578db41fc4e08d3656
출처 데이터셋
uspto-grants-1996_06
특허 번호
US05530019

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