Isobutylbenzene → 4'-Isobutylpentanophenone

HRID 260823노트

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HRID 260823 반응식
[C:1](Cl)(=[O:6])[CH2:2][CH2:3][CH2:4][CH3:5].[Cl-].[Al+3].[Cl-].[Cl-].[CH2:12]([C:16]1[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=1)[CH:13]([CH3:15])[CH3:14]>ClCCl>[CH2:12]([C:16]1[CH:21]=[CH:20][C:19]([C:1](=[O:6])[CH2:2][CH2:3][CH2:4][CH3:5])=[CH:18][CH:17]=1)[CH:13]([CH3:15])[CH3:14]

참가 물질

5

반응물 3

HCID 10870IsobutylbenzeneHCID 61186Valeryl chlorideHCID 6451240Aluminum(III) Chloride

생성물 1

HCID 109984904'-Isobutylpentanophenone

시약·촉매·용매 1

HCID 6344Dichloromethane용매

반응 조건

온도
0 °C

실험 절차

A mixture of valeryl chloride and aluminium chloride in dichloromethane was stirred at 0° C. for 30 minutes, and then isobutylbenzene was added. After stirring at 0° C. for 1 hour, the mixture was poured into ice water and extracted with dichloromethane. The organic layer was washed with an aqueous solution of sodium bicarbonate and brine, dried over magnesium sulfate and concentrated to give the object compound.

후처리

  1. stirringAfter stirring at 0° C. for 1 hour
  2. extractionextracted with dichloromethane
  3. washThe organic layer was washed with an aqueous solution of sodium bicarbonate and brine
  4. dry with materialdried over magnesium sulfate
  5. concentrationconcentrated
  6. customto give the object compound

출처 및 근거

ORD 기록
ord-5ece0742f6e64f89ba2410412f18cc4f
출처 데이터셋
uspto-grants-1996_06
특허 번호
US05530019

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