2-Chloroaniline → N-[2-(1-Azabicyclo[3.3.0]octan-5-yl)ethyl]-2-chloroaniline

HRID 260930노트

반응식

HRID 260930 반응식
[N+](C1C=CC=CC=1)([O-])=O.[Cl:10][C:11]1[CH:17]=[CH:16][CH:15]=[CH:14][C:12]=1[NH2:13].Cl[CH2:19][CH2:20][C:21]12[CH2:28][CH2:27][CH2:26][N:25]1[CH2:24][CH2:23][CH2:22]2.C(=O)([O-])[O-].[K+].[K+].[OH-].[Na+]>>[N:25]12[CH2:26][CH2:27][CH2:28][C:21]1([CH2:20][CH2:19][NH:13][C:12]1[CH:14]=[CH:15][CH:16]=[CH:17][C:11]=1[Cl:10])[CH2:22][CH2:23][CH2:24]2

참가 물질

6

반응물 5

HCID 72402-ChloroanilineHCID 7416NitrobenzeneHCID 11430Potassium CarbonateHCID 14798Sodium HydroxideHCID 107023655-(2-Chloroethyl)-1-azabicyclo[3.3.0]octane

생성물 1

HCID 10587741N-[2-(1-Azabicyclo[3.3.0]octan-5-yl)ethyl]-2-chloroaniline수율 40.1%

실험 절차

To nitrobenzene (30.0 ml), 2-chloroaniline (600 mg, 4.70 mmol), 5-(2-chloroethyl)-1-azabicyclo[3.3.0]octane (hydrochloride, 1.98 g, 9.42 mmol) and anhydrous potassium carbonate (3.90 g, 28.2 mmol) were added to react same for 10 hours at 120° C. subsequent to addition of 10% aqueous sodium hydroxide solution, the reaction mixture was extracted by ethyl acetate, washed by sodium chloride solution, dried over anhydrous sodium sulfate, concentrated in vacuo, and purified by column chromatography to afford the desired compound (499 mg, 40.1%), as a colorless liquid.

후처리

  1. extractionthe reaction mixture was extracted by ethyl acetate
  2. washwashed by sodium chloride solution
  3. dry with materialdried over anhydrous sodium sulfate
  4. concentrationconcentrated in vacuo
  5. custompurified by column chromatography

출처 및 근거

ORD 기록
ord-0c1f829bce154434a3551583abc00153
출처 데이터셋
uspto-grants-1996_06
특허 번호
US05530138

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