Dimethylformamide → HCID 178476927, 화합물

HRID 261015

반응식

HRID 261015 반응식
C([NH:4][C:5]([C:7]1[C:12]([NH2:13])=[N:11][C:10]([NH2:14])=[C:9]([Cl:15])[N:8]=1)=[O:6])(=N)N.C1C[N:23]2[C:18](=[N:19]CCC2)C1.[P:25](Cl)([O:29][CH2:30][CH3:31])[O:26][CH2:27][CH3:28].CN(C)C=[O:36]>>[NH2:13][C:12]1[C:7]([C:5]([NH:4][N:19]=[CH:18][NH:23][P:25](=[O:36])([O:29][CH2:30][CH3:31])[O:26][CH2:27][CH3:28])=[O:6])=[N:8][C:9]([Cl:15])=[C:10]([NH2:14])[N:11]=1

참가 물질

5

반응물 4

HCID 6228DimethylformamideHCID 68530Ethyl phosphorochloriditeHCID 763491,5-Diazabicyclo(4.3.0)non-5-eneHCID 178513083HCID 178513083, 화합물

생성물 1

HCID 178476927HCID 178476927, 화합물

반응 조건

온도
25 °C

실험 절차

A stirred solution of N-amidino-3,5-diamino-6-chloropyrazinamide (4.6 g., 0.02 mole) and DBN (2.5 g., 0.02 mole) in dimethylformamide (300 ml.) is cooled to 10° C. and treated with diethyl chlorophosphite (2.9 ml., 0.02 mole). The reaction is stirred at 25° C. for 3 hours, filtered and treated with ice water (300 ml.) to give diethyl N-[(3,5-diamino-6-chloro-pyrazinamido)iminomethyl]phosphoramidate which melts at 230° C. after recrystallization from ethanol-water.

후처리

  1. filtrationfiltered
  2. additiontreated with ice water (300 ml.)

출처 및 근거

ORD 기록
ord-960ab3d9ab704cd8b07c05ab4008cd5d
출처 데이터셋
uspto-grants-1979_08
특허 번호
US04163781

연결된 노트

불러오는 중…