Methyl iodide → 3,5-diamino-1-methyl-1H-pyrazole-4-carbonitrile

HRID 261072노트

반응식

HRID 261072 반응식
[NH2:1][C:2]1[C:6]([C:7]#[N:8])=[C:5]([NH2:9])[NH:4][N:3]=1.IC.[C:12](=O)([O-])[O-].[K+].[K+]>CC(C)=O>[NH2:1][C:2]1[C:6]([C:7]#[N:8])=[C:5]([NH2:9])[N:4]([CH3:12])[N:3]=1

참가 물질

5

반응물 3

HCID 6328Methyl iodideHCID 11430Potassium CarbonateHCID 142021413,5-Diamino-1H-pyrazole-4-carbonitrile

생성물 1

HCID 126210283,5-diamino-1-methyl-1H-pyrazole-4-carbonitrile수율 16.2%

시약·촉매·용매 1

HCID 180Acetone용매

실험 절차

3,5-Diamino-4-cyanopyrazole (6.1 g) prepared as in Example 3, iodomethane (3.1 ml), anhydrous potassium carbonate (7.6 g) and acetone (120 ml) were heated under reflux for 18 hours. The mixture was filtered, and the filtrate was concentrated to a viscous oil. Trituration of the oil with water gave a precipitate of 3,5-diamino-4-cyano-1-methylpyrazole (1.1 g), m.p. 194°-196° C.

후처리

  1. temperaturewere heated
  2. temperatureunder reflux for 18 hours
  3. filtrationThe mixture was filtered
  4. concentrationthe filtrate was concentrated to a viscous oil

출처 및 근거

ORD 기록
ord-027954cc5b4a46fdabac1c15a9c3705b
출처 데이터셋
uspto-grants-1979_08
특허 번호
US04163846

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