1,2-Dichlorobenzene → HCID 12593068, 화합물

HRID 261088

반응식

HRID 261088 반응식
[C:1]([CH2:4][C:5]1[CH:13]=[CH:12][CH:11]=[CH:10][C:6]=1[C:7]([OH:9])=O)([OH:3])=O.[NH2:14][C:15]([CH3:19])([CH3:18])[CH2:16]O.ClC1C=CC=CC=1Cl>C(OCC)(=O)C>[CH3:16][C:15]1([CH3:19])[N:14]2[C:7](=[O:9])[C:6]3[CH:10]=[CH:11][CH:12]=[CH:13][C:5]=3[CH:4]=[C:1]2[O:3][CH2:18]1

참가 물질

5

반응물 3

HCID 72391,2-DichlorobenzeneHCID 118072-Amino-2-methyl-1-propanolHCID 66643Homophthalic acid

생성물 1

HCID 12593068HCID 12593068, 화합물

시약·촉매·용매 1

HCID 8857Ethyl Acetate용매

실험 절차

A mixture of 1 g. of 2-carboxymethylbenzoic acid, 0.5 g. of 2-amino-2-methylpropanol, and 5 ml. of o-dichlorobenzene was heated to 150°-160° C. for 4 hours. After cooling, the solvent was distilled off from the reaction mixture under reduced pressure and the residue obtained was dissolved in 30 ml. of ethyl acetate. Then, the solution was successively washed with diluted hydrochloric acid, a diluted sodium carbonate solution, and water, dried over anhydrous magnesium sulfate, and then the solvent was distilled off under reduced pressure. By recrystallizing the residue obtained from cyclohexane, 700 mg. of 3,3-dimethyl-5-oxo-2,3-dihydro-5H-oxazolo[3,2-b]isoquinoline was obtained.

후처리

  1. additionA mixture of 1 g
  2. temperatureAfter cooling
  3. distillationthe solvent was distilled off from the reaction mixture under reduced pressure
  4. customthe residue obtained
  5. dissolutionwas dissolved in 30 ml
  6. washThen, the solution was successively washed with diluted hydrochloric acid
  7. dry with materiala diluted sodium carbonate solution, and water, dried over anhydrous magnesium sulfate
  8. distillationthe solvent was distilled off under reduced pressure
  9. customBy recrystallizing the residue
  10. customobtained from cyclohexane, 700 mg

출처 및 근거

ORD 기록
ord-01c7e97a20e746d9b911478af0345b12
출처 데이터셋
uspto-grants-1979_08
특허 번호
US04163844

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