2-Nitro-4-(trifluoromethyl)phenol → 2-Amino-4-(trifluoromethyl)phenol
반응식
[N+:1]([C:4]1[CH:9]=[C:8]([C:10]([F:13])([F:12])[F:11])[CH:7]=[CH:6][C:5]=1[OH:14])([O-])=O>C(O)C.[Pt]=O>[NH2:1][C:4]1[CH:9]=[C:8]([C:10]([F:11])([F:12])[F:13])[CH:7]=[CH:6][C:5]=1[OH:14]참가 물질
4
실험 절차
82.2 g of 6A was dissolved in 300 ml of ethanol. 0.5 g of platinum oxide catalyst was added and the mixture was hydrogenated at 50 psig. Fresh portions of catalyst were added periodically. The reaction mixture was filtered, and the filtrate was concentrated. The residue was crystallized from water to give 2-amino-4-(trifluoromethyl)phenol (6B).
후처리
- additionFresh portions of catalyst were added periodically
- filtrationThe reaction mixture was filtered
- concentrationthe filtrate was concentrated
- customThe residue was crystallized from water
출처 및 근거
- ORD 기록
- ord-059b6ae66e85466a99b629334c527693
- 출처 데이터셋
- uspto-grants-1979_08
- 특허 번호
- US04164576
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