1,3-Dichloroacetone → HCID 178479412, 화합물
반응식
[C:1]([NH:4][C:5]([NH2:7])=[S:6])(=[NH:3])[NH2:2].[Cl:8][CH2:9][C:10]([CH2:12]Cl)=O>CC(C)=O>[ClH:8].[NH:4]([C:5]1[S:6][CH:12]=[C:10]([CH2:9][Cl:8])[N:7]=1)[C:1]([NH2:2])=[NH:3]참가 물질
4
실험 절차
A suspension of amidinothiourea (16.8 g.) in acetone (75 ml.) was treated with 1,3-dichloroacetone (18 g.) in acetone (60 ml.). There was a slight exotherm and the crystalline suspension gradually changed to a fine white solid. After stirring overnight at room temperature the solid was filtered off and washed with acetone. Crystallization from ethanol gave 2-guanidino-4-chloromethylthiazole hydrochloride, m.p. 191°-193° C.
후처리
- filtrationwas filtered off
- washwashed with acetone
- customCrystallization from ethanol
출처 및 근거
- ORD 기록
- ord-1452d09017684dff86411c91d4388d46
- 출처 데이터셋
- uspto-grants-1979_08
- 특허 번호
- US04165378
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