Htris → 2-(2-Isopropyl-5-indanyl)propionic acid

HRID 261525

반응식

HRID 261525 반응식
[CH:1]([CH:4]1[CH2:12][C:11]2[C:6](=[CH:7][CH:8]=[C:9]([C:13](=[CH2:17])[C:14]([OH:16])=[O:15])[CH:10]=2)[CH2:5]1)([CH3:3])[CH3:2].OCC([NH3+])(CO)CO>C(O)C.[Pt](=O)=O>[CH:1]([CH:4]1[CH2:12][C:11]2[C:6](=[CH:7][CH:8]=[C:9]([CH:13]([CH3:17])[C:14]([OH:16])=[O:15])[CH:10]=2)[CH2:5]1)([CH3:3])[CH3:2]

참가 물질

5

반응물 2

HCID 3777159HtrisHCID 542342992-Isopropyl-alpha-methylene-5-indanacetic acid

생성물 1

HCID 687692-(2-Isopropyl-5-indanyl)propionic acid

시약·촉매·용매 2

HCID 345198Adams' catalyst촉매HCID 702Ethanol용매

실험 절차

A solution of 1.7 g of 2-isopropyl-α-methylene-5-indanacetic acid in 300 cc of ethanol is hydrogenated at room temperature with the addition of 50 mg of platinum(IV) oxide. After filtering off the catalyst, removing the solvent by evaporation and chromatographing the resulting oil, 2-isopropyl-α-methyl-5-indanacetic acid, having a M.P. of 83°-86°, is obtained. The (1,3-dihydroxy-2-hydroxymethyl-2-propyl)ammonium salt of the title compound has a M.P. of 140°-141° (from methanol/ether).

후처리

  1. filtrationAfter filtering off the catalyst
  2. customremoving the solvent
  3. customby evaporation and chromatographing the resulting oil, 2-isopropyl-α-methyl-5-indanacetic acid
  4. customis obtained

출처 및 근거

ORD 기록
ord-df1cdc89f3144844b82437d920b8d357
출처 데이터셋
uspto-grants-1979_08
특허 번호
US04166131

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