Hydrochloric Acid → 2-Ethyl-2-methyl-indan

HRID 261529

반응식

HRID 261529 반응식
Cl.[CH2:2]([C:4]1([CH3:14])[CH2:12][C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[C:5]1=O)[CH3:3]>O.C(O)C.[Zn].C([O-])(=O)C.[Hg+2].C([O-])(=O)C>[CH2:2]([C:4]1([CH3:14])[CH2:12][C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[CH2:5]1)[CH3:3]

참가 물질

7

반응물 2

HCID 313Hydrochloric AcidHCID 146860942-Ethyl-2-methyl-1-indanone

생성물 1

HCID 203944402-Ethyl-2-methyl-indan

시약·촉매·용매 4

HCID 15337Mercuric acetate촉매HCID 23994Zinc촉매HCID 702Ethanol용매HCID 962Water용매

실험 절차

335 g of zinc dust and 33.5 g of mercury (II) acetate and a solution of 330 cc of concentrated hydrochloric acid in 280 cc of water are rapidly added dropwise in a stirring apparatus. The mixture is boiled at reflux and a solution of 63 g of 2-ethyl-2-methyl-1-indanone in 525 cc of ethanol is added dropwise within 10 minutes while stirring. The reaction mixture is subsequently stirred at reflux for 28 hours, cooled, filtered, and the residue is washed with water/petroleum ether. The filtrate is extracted with petroleum ether, the petroleum ether extract is washed with water and dried over sodium sulphate. The crude 2-ethyl-2-methyl-indan, obtained as an oil after evaporating the solvent, is purified by chromatography on aluminium oxide/petroleum ether.

후처리

  1. temperatureat reflux
  2. stirringThe reaction mixture is subsequently stirred
  3. temperatureat reflux for 28 hours
  4. temperaturecooled
  5. filtrationfiltered
  6. washthe residue is washed with water/petroleum ether
  7. extractionThe filtrate is extracted with petroleum ether
  8. extractionthe petroleum ether extract
  9. washis washed with water
  10. dry with materialdried over sodium sulphate

출처 및 근거

ORD 기록
ord-28adf486cf104b4d8d97dd240ed54f30
출처 데이터셋
uspto-grants-1979_08
특허 번호
US04166131

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