Potassium thiocyanate → 4-(4-Benzamidobutyl)-5-methylimidazole-2-thione

HRID 261619노트

반응식

HRID 261619 반응식
Cl.[NH2:2][CH:3]([CH2:7][CH2:8][CH2:9][CH2:10][NH:11][C:12](=[O:19])[C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1)[C:4](=O)[CH3:5].[S-:20][C:21]#[N:22].[K+]>O>[C:12]([NH:11][CH2:10][CH2:9][CH2:8][CH2:7][C:3]1[C:4]([CH3:5])=[N:22][C:21](=[S:20])[N:2]=1)(=[O:19])[C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1

참가 물질

4

반응물 2

HCID 516872Potassium thiocyanateHCID 203945683-Amino-7-benzamidoheptan-2-one hydrochloride

생성물 1

HCID 203945574-(4-Benzamidobutyl)-5-methylimidazole-2-thione수율 25.3%

시약·촉매·용매 1

HCID 962Water용매

실험 절차

A solution of 3-amino-7-benzamidoheptan-2-one hydrochloride (16.39 g, 0.0576 mol) and potassium thiocyanate (7.30 g, 0.0755 mol, excess) in water was heated under reflux for 20 hours. The aquesus phase was decanted off and the organic phase was washed with water, and recrystallised from acetonitrile to give 4-(4-benzamidobutyl)-5-methylimidazole-2-thione (4.18 g, 25%) m.p. 180°-184°.

후처리

  1. temperatureunder reflux for 20 hours
  2. customThe aquesus phase was decanted off
  3. washthe organic phase was washed with water
  4. customrecrystallised from acetonitrile

출처 및 근거

ORD 기록
ord-d1526fc277ce41089995dc0eceed56f5
출처 데이터셋
uspto-grants-1979_08
특허 번호
US04166184

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