Ethyl 2-methoxyimino-2-(2-aminothiazol-4-yl)acetate hydrobromide → 2-(2-Aminothiazole-4-yl)-2-methoxyiminoacetic acid

HRID 261693

반응식

HRID 261693 반응식
Br.[CH3:2][O:3][N:4]=[C:5]([C:11]1[N:12]=[C:13]([NH2:16])[S:14][CH:15]=1)[C:6]([O:8]CC)=[O:7]>[OH-].[Na+].O>[CH3:2][O:3][N:4]=[C:5]([C:11]1[N:12]=[C:13]([NH2:16])[S:14][CH:15]=1)[C:6]([OH:8])=[O:7]

참가 물질

4

반응물 1

HCID 73668749Ethyl 2-methoxyimino-2-(2-aminothiazol-4-yl)acetate hydrobromide

생성물 1

HCID 1252162-(2-Aminothiazole-4-yl)-2-methoxyiminoacetic acid수율 79.6%

시약·촉매·용매 2

HCID 962Water용매HCID 14798Sodium Hydroxide용매

실험 절차

Ethyl 2-methoxyimino-2-(2-amino-1,3-thiazol-4-yl)acetate hydrobromide (anti isomer) (15.5 g.) was dissolved in a solution of sodium hydroxide (4.4 g.) in water (150 ml.) and the resulting solution was stirred for 1 hour at ambient temperature. An insoluble material was filtered off and the filtrate was adjusted to pH 5.0 to precipitate crystals. The crystals were collected by filtration and dried to give 2-methoxyimino-2-(2-amino-1,3-thiazol-4-yl)acetic acid (anti isomer) (8.0 g.).

후처리

  1. filtrationAn insoluble material was filtered off
  2. customto precipitate crystals
  3. filtrationThe crystals were collected by filtration
  4. customdried

출처 및 근거

ORD 기록
ord-162180bcda7e45399c4948162554dbeb
출처 데이터셋
uspto-grants-1979_08
특허 번호
US04166115

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