Dimethylformamide → 3,5-diphenyl-4(1H)-pyridone

HRID 261774

반응식

HRID 261774 반응식
[C:1]1([CH2:7][C:8](=[O:16])[CH2:9][C:10]2[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[CH:17]([NH:19][CH:20](NC=O)NC=O)=O.CN(C)C=O>O>[C:1]1([C:7]2[C:8](=[O:16])[C:9]([C:10]3[CH:11]=[CH:12][CH:13]=[CH:14][CH:15]=3)=[CH:20][NH:19][CH:17]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1

참가 물질

5

반응물 3

HCID 6228DimethylformamideHCID 75931,3-Diphenyl-2-propanoneHCID 78505N,N',N''-Methylidynetrisformamide

생성물 1

HCID 124666803,5-diphenyl-4(1H)-pyridone

시약·촉매·용매 1

HCID 962Water용매

실험 절차

A 1.4 g. portion of 1,3-diphenyl-2-propanone was mixed with 1.0 g. of tris(formylamino)methane in 20 ml. of dimethylformamide. The reaction mixture was stirred at reflux temperature for 3 hours. The mixture was then cooled to approximately room temperature, and poured into water. The precipitated solids were separated by filtration, and the solids were suspended in chloroform. The chloroform was then filtered, and the solids remaining were washed first with water, and then with chloroform. The yield was about 100 mg. of 3,5-diphenyl-4(1H)-pyridone, m.p. greater than 335° C.

후처리

  1. temperatureat reflux temperature for 3 hours
  2. temperatureThe mixture was then cooled to approximately room temperature
  3. customThe precipitated solids were separated by filtration
  4. filtrationThe chloroform was then filtered
  5. washthe solids remaining were washed first with water

출처 및 근거

ORD 기록
ord-2a7aa077b06e428d88b89725156bd94f
출처 데이터셋
uspto-grants-1979_05
특허 번호
US04152136

연결된 노트

불러오는 중…