UP 614-04 → 2-(1-Phenyl-6-chloro-2,3-dihydro-benzimidazol-2-on-3-yl-methyl)-morpholine maleate

HRID 261784

반응식

HRID 261784 반응식
Cl.C([N:9]1[CH2:14][CH2:13][O:12][CH:11]([CH2:15][N:16]2[C:20]3[CH:21]=[CH:22][C:23]([Cl:25])=[CH:24][C:19]=3[N:18]([C:26]3[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=3)[C:17]2=[O:32])[CH2:10]1)C1C=CC=CC=1.Cl.CN1C2C=CC=CC=2N(CC2OCCNC2)C1=O.[C:52]([OH:59])(=[O:58])/[CH:53]=[CH:54]\[C:55]([OH:57])=[O:56]>C(O)(C)C>[C:52]([OH:59])(=[O:58])/[CH:53]=[CH:54]\[C:55]([OH:57])=[O:56].[C:26]1([N:18]2[C:19]3[CH:24]=[C:23]([Cl:25])[CH:22]=[CH:21][C:20]=3[N:16]([CH2:15][CH:11]3[O:12][CH2:13][CH2:14][NH:9][CH2:10]3)[C:17]2=[O:32])[CH:27]=[CH:28][CH:29]=[CH:30][CH:31]=1

참가 물질

5

반응물 3

HCID 134375UP 614-04HCID 444266Maleic AcidHCID 706018024-Benzyl-2-(1-phenyl-6-chloro-2,3-dihydro-benzimidazol-2-on-3-yl-methyl)-morpholine hydrochloride

생성물 1

HCID 867360812-(1-Phenyl-6-chloro-2,3-dihydro-benzimidazol-2-on-3-yl-methyl)-morpholine maleate

시약·촉매·용매 1

HCID 3776Isopropanol용매2회

실험 절차

30 g of 4-benzyl-2-(1-phenyl-6-chloro-2,3-dihydro-benzimidazol-2-on-3-yl-methyl)-morpholine hydrochloride are treated as in part (a) of Example 2. After evaporation of the solvent under reduced pressure, 20 g of an oily product are obtained and are dissolved in hot isopropyl alcohol. A hot solution of maleic acid in isopropanol is added. The salt precipitates slowly, 19 g of 2-(1-phenyl-6-chloro-2,3-dihydro-benzimidazol-2-on-3-yl-methyl)-morpholine maleate are obtained, m.p. 234° C.

후처리

  1. customAfter evaporation of the solvent under reduced pressure, 20 g of an oily product
  2. customare obtained
  3. customThe salt precipitates slowly

출처 및 근거

ORD 기록
ord-b09a96f4040e4c838a7acfab84df7701
출처 데이터셋
uspto-grants-1979_05
특허 번호
US04152434

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