Hydrochloric Acid → 1,6-Dihydro-4-hydroxy-1-methyl-2-methoxy-6-oxo-pyrimidine
반응식
[OH:1][C:2]1[N:3]=[C:4](SC)[N:5]([CH3:9])[C:6](=[O:8])[CH:7]=1.[CH3:12][OH:13].Cl>CCOCC>[OH:1][C:2]1[N:3]=[C:4]([O:13][CH3:12])[N:5]([CH3:9])[C:6](=[O:8])[CH:7]=1참가 물질
5
실험 절차
A mixture of 172 g (1 mol) of 1,6-dihydro-4-hydroxy-1-methyl-2-methylthio-6-oxo-pyrimidine, 700 ml of methanol and 5 ml of a solution of hydrogen chloride in ether was boiled for 10 days under reflux. The reaction mixture was then filtered while still hot and the filtrate is evaporated in vacuo. The residue was triturated with ether and the crystalline product was filtered off. In this way, 71 g (40% of theory) of 1,6-dihydro-4-hydroxy-1-methyl-2-methoxy-6-oxo-pyrimidine were obtained in the form of colorless crystals of melting point 170°-171° C. ##STR11##
후처리
- temperatureunder reflux
- filtrationThe reaction mixture was then filtered while still hot and the filtrate
- customis evaporated in vacuo
- customThe residue was triturated with ether
- filtrationthe crystalline product was filtered off
출처 및 근거
- ORD 기록
- ord-be41bb75b42b464f9fa7713bb4e877ed
- 출처 데이터셋
- uspto-grants-1979_05
- 특허 번호
- US04152426
반응 노트
불러오는 중…