Phenylacetyl chloride → N-Phenylmethyl-N-(5-Methyl-1,3,4-thiadiazol-2-yl)-benzene acetamide

HRID 261793노트

반응식

HRID 261793 반응식
[CH3:1][C:2]1[S:6][C:5]([NH:7][CH2:8][C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=2)=[N:4][N:3]=1.[C:15]1([CH2:21][C:22](Cl)=[O:23])[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1>N1C=CC=CC=1>[C:9]1([CH2:8][N:7]([C:5]2[S:6][C:2]([CH3:1])=[N:3][N:4]=2)[C:22](=[O:23])[CH2:21][C:15]2[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=2)[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1

참가 물질

4

반응물 2

HCID 7679Phenylacetyl chlorideHCID 6460923N-benzyl-5-methyl-1,3,4-thiadiazol-2-amine

생성물 1

HCID 5324449N-Phenylmethyl-N-(5-Methyl-1,3,4-thiadiazol-2-yl)-benzene acetamide

시약·촉매·용매 1

HCID 1049Pyridine용매

실험 절차

N-(5-Methyl-1,3,4-thiadiazol-2-yl)-benzylamine (15 g, 0.073 mole) in pyridine (200 ml) was refluxed with phenylacetyl chloride for 6 hours. The pyridine was removed under educed pressure and the residue treated with water and extracted with ether. The ethereal solution was dried, filtered and evaporated to dryness and the residue recrystallised from ethanol to give the title compound, m.p. 128° C.

후처리

  1. customThe pyridine was removed
  2. additionthe residue treated with water
  3. extractionextracted with ether
  4. customThe ethereal solution was dried
  5. filtrationfiltered
  6. customevaporated to dryness
  7. customthe residue recrystallised from ethanol

출처 및 근거

ORD 기록
ord-c773410a1c9b481b9002b3e0c96ae329
출처 데이터셋
uspto-grants-1979_05
특허 번호
US04152442

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