Sodium borohydride → N-(o-Chlorobenzyl)-2-methyl-3-chloroaniline

HRID 261823노트

반응식

HRID 261823 반응식
[Cl:1][C:2]1[CH:17]=[CH:16][CH:15]=[CH:14][C:3]=1[CH:4]=[N:5][C:6]1[CH:11]=[CH:10][CH:9]=[C:8]([Cl:12])[C:7]=1[CH3:13].[BH4-].[Na+]>CO.O>[Cl:1][C:2]1[CH:17]=[CH:16][CH:15]=[CH:14][C:3]=1[CH2:4][NH:5][C:6]1[CH:11]=[CH:10][CH:9]=[C:8]([Cl:12])[C:7]=1[CH3:13]

참가 물질

5

반응물 2

HCID 4311764Sodium borohydrideHCID 13017551N-(o-Chlorobenzylidene)-2-methyl-3-chloroaniline

생성물 1

HCID 21321344N-(o-Chlorobenzyl)-2-methyl-3-chloroaniline

시약·촉매·용매 2

HCID 887Methanol용매HCID 962Water용매

실험 절차

A suspension of N-(o-chlorobenzylidene)-2-methyl-3-chloroaniline (0.038 mole) is brought to reflux in 100 cc of absolute methanol. An equivalent of sodium borohydride (1.5 g.) is added in portions and refluxing is continued for 15 mins. The reaction mixture is cooled and diluted with an equal volume of cold water to precipitate a solid. This material is collected, washed with H2O and air dried. Recrystallization from ethanol gives N-(o-Chlorobenzyl)-2-methyl-3-chloroaniline. m.p. 63°-66° C.

후처리

  1. temperaturerefluxing
  2. temperatureThe reaction mixture is cooled
  3. customto precipitate a solid
  4. customThis material is collected
  5. washwashed with H2O and air
  6. customdried
  7. customRecrystallization from ethanol

출처 및 근거

ORD 기록
ord-7a8529161f27459898c0d6297c3f8657
출처 데이터셋
uspto-grants-1979_05
특허 번호
US04152452

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