Methyl Isocyanate → N-(3-methyl-5-isothiazolyl)-N'-methylurea
반응식
[CH3:1][N:2]=[C:3]=[O:4].[NH2:5][C:6]1[S:10][N:9]=[C:8]([CH3:11])[CH:7]=1>O1CCCC1>[CH3:11][C:8]1[CH:7]=[C:6]([NH:5][C:3]([NH:2][CH3:1])=[O:4])[S:10][N:9]=1참가 물질
4
실험 절차
Methylisocyanate (1.96 milliliters, 0.04 mole) was added dropwise to a thirty (30) milliliter solution of the distilled tetrahydrofuran containing the above mentioned 5-amino-3-methylisothiazole (5.0 grams, 0.04 mole), and then the resulting yellow solution was refluxed for 3 hours, during which time a white precipitate formed. The solution was cooled and filtered, giving 3.73 grams of N-(3-methyl-5-isothiazolyl)-N'-methylurea, also referred to as 3-methyl-5-N-methylureiodisothiazole.
후처리
- temperaturethe resulting yellow solution was refluxed for 3 hours, during which time a white precipitate
- customformed
- temperatureThe solution was cooled
- filtrationfiltered
출처 및 근거
- ORD 기록
- ord-5292de97bb924efc96de2b966bd65664
- 출처 데이터셋
- uspto-grants-1979_05
- 특허 번호
- US04152516
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