Acetic Acid → (4-chlorophenyl)(1H-imidazol-2-yl)phenylmethanol

HRID 261936

반응식

HRID 261936 반응식
C(OC[N:10]1[CH:14]=[CH:13][N:12]=[C:11]1[C:15]([C:23]1[CH:28]=[CH:27][C:26]([Cl:29])=[CH:25][CH:24]=1)([C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1)[OH:16])C1C=CC=CC=1.C(O)(=O)C.Cl>O>[Cl:29][C:26]1[CH:25]=[CH:24][C:23]([C:15]([C:17]2[CH:18]=[CH:19][CH:20]=[CH:21][CH:22]=2)([C:11]2[NH:12][CH:13]=[CH:14][N:10]=2)[OH:16])=[CH:28][CH:27]=1

참가 물질

5

반응물 3

HCID 176Acetic AcidHCID 313Hydrochloric AcidHCID 124339151-[(Benzyloxy)methyl]-alpha-(p-chlorophenyl)-alpha-phenylimidazole-2-methanol

생성물 1

HCID 12433863(4-chlorophenyl)(1H-imidazol-2-yl)phenylmethanol

시약·촉매·용매 1

HCID 962Water용매

실험 절차

About 17 g. (0.042 mol) of 1-[(benzyloxy)methyl]-α-(p-chlorophenyl)-α-phenylimidazole-2-methanol was boiled under reflux in a mixture of 85 ml. of glacial acetic acid, 8.5 ml. of water and 8.5 ml. of concentrated hydrochloric acid solution. Acetic acid was removed by evaporation and the base was liberated by addition of 2 N sodium hydroxide solution. It was crystallised from isopropyl alcohol. Melting point of the product was 162°-165° C.

후처리

  1. temperatureunder reflux in a mixture of 85 ml
  2. customAcetic acid was removed by evaporation
  3. additionthe base was liberated by addition of 2 N sodium hydroxide solution
  4. customIt was crystallised from isopropyl alcohol
  5. customwas 162°-165° C.

출처 및 근거

ORD 기록
ord-cceeaee25d9846e69e81e02792f0e7c9
출처 데이터셋
uspto-grants-1979_05
특허 번호
US04152441

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