1-Methylpiperazine → HCID 47864, 화합물

HRID 262064노트

반응식

HRID 262064 반응식
[C:1]([NH:4][C:5]1[C:6]([O:18][CH2:19][CH2:20]Cl)=[C:7]([O:16][CH3:17])[C:8]2[O:12][CH:11]=[CH:10][C:9]=2[C:13]=1[O:14][CH3:15])(=[O:3])[CH3:2].[CH3:22][N:23]1[CH2:28][CH2:27][NH:26][CH2:25][CH2:24]1>C1(C)C=CC=CC=1>[C:1]([NH:4][C:5]1[C:6]([O:18][CH2:19][CH2:20][N:26]2[CH2:27][CH2:28][N:23]([CH3:22])[CH2:24][CH2:25]2)=[C:7]([O:16][CH3:17])[C:8]2[O:12][CH:11]=[CH:10][C:9]=2[C:13]=1[O:14][CH3:15])(=[O:3])[CH3:2]

참가 물질

4

반응물 2

HCID 531671-MethylpiperazineHCID 12672371HCID 12672371, 화합물

생성물 1

HCID 47864HCID 47864, 화합물

시약·촉매·용매 1

HCID 1140Toluene용매

실험 절차

A solution of 15.5 g (0.05 mole) of 5-acetamido 6-(2-chloro ethoxy) 4,7dimethoxy benzofuran prepared in the preceding example and 15 g (0.15 mole) of N-methyl piperazine was brought to reflux for 8 hours in 100 ml of toluene. It was filtered and the filtrate evaporated under vacum the residue was taken up again in alcohol and hydrochloric alcohol was added. It was filtered and recrystallized in absolute alcohol.

후처리

  1. filtrationIt was filtered
  2. customthe filtrate evaporated under vacum the residue
  3. additionhydrochloric alcohol was added
  4. filtrationIt was filtered
  5. customrecrystallized in absolute alcohol

출처 및 근거

ORD 기록
ord-3a2f50e14bf6486990050ba1f006c2ba
출처 데이터셋
uspto-grants-1979_05
특허 번호
US04153620

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