Water → 7-Bromo-5-methyl-3-phenylbenzofuran

HRID 262089

반응식

HRID 262089 반응식
[Br:1][C:2]1[CH:17]=[C:16]([CH3:18])[CH:15]=[CH:14][C:3]=1[O:4][CH2:5][C:6]([C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1)=O.O>C(Cl)(Cl)Cl>[Br:1][C:2]1[C:3]2[O:4][CH:5]=[C:6]([C:8]3[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=3)[C:14]=2[CH:15]=[C:16]([CH3:18])[CH:17]=1

참가 물질

4

반응물 2

HCID 962WaterHCID 40772362-(2-Bromo-4-methylphenoxy)acetophenone

생성물 1

HCID 213199287-Bromo-5-methyl-3-phenylbenzofuran

시약·촉매·용매 1

HCID 6212Chloroform용매

실험 절차

A mixture of 700 g. of polyphosphoric acid and 100 g. of α-(2-bromo-4-methylphenoxy)acetophenone is heated at 80°-90° C. for two hours, then poured into two liters of water with stirring. Chloroform (1 liter) is added, and the phases are separated. The organic layer is washed with water, dried, then evaporated to provide 7-bromo-5-methyl-3-phenylbenzofuran as a brown oil.

후처리

  1. additionA mixture of 700 g
  2. customthe phases are separated
  3. washThe organic layer is washed with water
  4. customdried
  5. customevaporated

출처 및 근거

ORD 기록
ord-8e550f305de947eaa87715bf888aacd9
출처 데이터셋
uspto-grants-1979_05
특허 번호
US04153619

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