3-Phenylindole → 3-phenyl-2,3-dihydro-1H-indole

HRID 262288

반응식

HRID 262288 반응식
[C:1]1([C:7]2[C:15]3[C:10](=[CH:11][CH:12]=[CH:13][CH:14]=3)[NH:9][CH:8]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.B(F)(F)F.F>[Pd].C(O)C>[C:1]1([CH:7]2[C:15]3[C:10](=[CH:11][CH:12]=[CH:13][CH:14]=3)[NH:9][CH2:8]2)[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1

참가 물질

5

반응물 2

HCID 965023-PhenylindoleHCID 9855450Trifluoroborane Hydrofluoride

생성물 1

HCID 109323533-phenyl-2,3-dihydro-1H-indole수율 47%

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 702Ethanol용매

실험 절차

A mixture of 4.0 g of 3-phenylindole, 80 ml of 86% ethanol, 35 ml of 48% hydrofluoroboric acid and 0.25 g of 10% Pd/C was hydrogenated at 60 p.s.i. and 60° C. for 18 hours. The reaction mixture was worked up as in Example 2 and 1.9 g of pure 3-phenylindoline was obtained.

출처 및 근거

ORD 기록
ord-0a4712bbb69d4e66aa50b5d642860249
출처 데이터셋
uspto-grants-1979_05
특허 번호
US04153789

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