Hydrochloric Acid → alpha,alpha-Bis[2-(diisopropylamino)ethyl]-alpha-phenylacetamide dihydrochloride

반응식

[CH:1]([N:4]([CH:26]([CH3:28])[CH3:27])[CH2:5][CH2:6][C:7]([CH2:17][CH2:18][N:19]([CH:23]([CH3:25])[CH3:24])[CH:20]([CH3:22])[CH3:21])([C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1)[C:8]([NH2:10])=[O:9])([CH3:3])[CH3:2].CCOCC.[ClH:34]>C(O)(C)C>[ClH:34].[ClH:34].[CH:23]([N:19]([CH:20]([CH3:22])[CH3:21])[CH2:18][CH2:17][C:7]([CH2:6][CH2:5][N:4]([CH:1]([CH3:3])[CH3:2])[CH:26]([CH3:28])[CH3:27])([C:11]1[CH:12]=[CH:13][CH:14]=[CH:15][CH:16]=1)[C:8]([NH2:10])=[O:9])([CH3:24])[CH3:25]

참가 물질

실험 절차

To a solution of 10 parts of α,α-bis[2-(diisopropylamino)ethyl]-α-phenylacetamide in 350 parts by volume of ether is added dropwise with stirring 2 molar equivalents of hydrochloric acid in isopropyl alcohol. The mixture is stirred for about 2 hours when the resulting salt is separated by filtration to afford α,α-bis[2-(diisopropylamino)ethyl]-α-phenylacetamide dihydrochloride, melting at about 140° C.