1,3-Propanediol → HCID 178520883, 화합물

HRID 262609

반응식

HRID 262609 반응식
[Na].Cl.Cl[CH2:4][C:5]1[N:6]=[CH:7][NH:8][CH:9]=1.[CH2:10]([OH:14])[CH2:11][CH2:12][OH:13]>>[OH:13][CH2:12][CH2:11][CH2:10][O:14][CH2:4][C:5]1[N:6]=[CH:7][NH:8][CH:9]=1

참가 물질

4

반응물 3

HCID 104421,3-PropanediolHCID 5360545SodiumHCID 178478565HCID 178478565, 화합물

생성물 1

HCID 178520883HCID 178520883, 화합물

실험 절차

Sodium (13.5 g.) was added over 3-hours to propane1,3-diol (450 ml.) under nitrogen at 70° with stirring. This solution was added over 20 minutes to a stirred solution of 4-chloromethylimidazole hydrochloride (50.0 g.) under nitrogen at 40°-60°. Subsequent heating at 60°-65° for 3 hours followed by overnight cooling, filtration and concentration gave 4-(3-hydroxypropoxy)methylimidazole. Subsequent reaction with thionyl chloride gave 4-(3-chloropropoxy)methylimidazole hydrochloride (38.3 g.).

후처리

  1. temperatureSubsequent heating at 60°-65° for 3 hours
  2. temperaturecooling
  3. filtrationfiltration and concentration

출처 및 근거

ORD 기록
ord-11b76ae3c08f442a9266a3ba2b19d6d9
출처 데이터셋
uspto-grants-1979_05
특허 번호
US04154844

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