Ethylenediamine → N-(2-thiazolylmethyl)ethylenediamine

HRID 262671노트

반응식

HRID 262671 반응식
[CH2:1]([NH2:4])[CH2:2][NH2:3].Cl[CH2:6][C:7]1[S:8][CH:9]=[CH:10][N:11]=1>>[S:8]1[CH:9]=[CH:10][N:11]=[C:7]1[CH2:6][NH:3][CH2:2][CH2:1][NH2:4]

참가 물질

3

반응물 2

HCID 3301EthylenediamineHCID 140908642-(Chloromethyl)-1,3-thiazole

생성물 1

HCID 17944882N-(2-thiazolylmethyl)ethylenediamine

실험 절차

Reacting ethylenediamine with 2-chloromethylthiazole by the procedure of Example 34 gives N-(2-thiazolylmethyl)ethylenediamine. Reacting this intermediate with S-methyl-N-nitroisothiourea by the procedure of Example 2(ii) gives N-nitro-N'-[2-(2-thiazolylmethylamino)ethyl]guanidine. Treatment with hydrobromic acid gives the hydrobromide salt.

출처 및 근거

ORD 기록
ord-6e605e89ec29448c8e0d3bbc1b7c143e
출처 데이터셋
uspto-grants-1979_05
특허 번호
US04154844

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