Methane → Ethyl 2-(2-Amino-4-thiazolyl)-2-oxoacetate

HRID 2628

반응식

HRID 2628 반응식
Br[CH2:2][C:3]([C:5](=[O:11])[C:6]([O:8][CH2:9][CH3:10])=[O:7])=O.[NH2:12][C:13]([NH2:15])=[S:14].C>O.C(O)C>[NH2:15][C:13]1[S:14][CH:2]=[C:3]([C:5](=[O:11])[C:6]([O:8][CH2:9][CH3:10])=[O:7])[N:12]=1

참가 물질

6

반응물 3

HCID 297MethaneHCID 2723790ThioureaHCID 13455954Ethyl bromoacetylglyoxylate

생성물 1

HCID 4356513Ethyl 2-(2-Amino-4-thiazolyl)-2-oxoacetate

시약·촉매·용매 2

HCID 702Ethanol용매HCID 962Water용매

실험 절차

195 g of ethyl bromoacetylglyoxylate are added dropwise to a solution of 66 g of thiourea in 450 ml of water and 450 ml of ethanol at 5° and after the addition has ended, the mixture is stirred at room temperature for 30 minutes and at 50° for 30 minutes and, after adding active charcoal, the resulting reaction mixture is then filtered. The filtrate is brought to pH 7 by adding sodium bicarbonate solution, whereupon ethyl 2-amino-thiazol-4-ylglyoxylate crystallizes out in crystals of melting point 147°.

후처리

  1. additionafter the addition
  2. customthe resulting reaction mixture
  3. filtrationis then filtered
  4. additionby adding sodium bicarbonate solution
  5. customwhereupon ethyl 2-amino-thiazol-4-ylglyoxylate crystallizes out in crystals of melting point 147°

출처 및 근거

ORD 기록
ord-3c1efdc8bce441deb9547de62f031a43
출처 데이터셋
uspto-grants-1998_03
특허 번호
USRE035754

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