Methyl iodide → 1-Iodo-3-methyloct-1-en-3-ol

HRID 262854

반응식

HRID 262854 반응식
[Mg].[CH3:2]I.[I:4][CH:5]=[CH:6][C:7](=[O:13])[CH2:8][CH2:9][CH2:10][CH2:11][CH3:12].[Cl-].[NH4+]>CCOCC>[OH:13][C:7]([CH3:2])([CH2:8][CH2:9][CH2:10][CH2:11][CH3:12])[CH:6]=[CH:5][I:4]

참가 물질

6

반응물 4

HCID 6328Methyl iodideHCID 25517Ammonium ChlorideHCID 5462224MagnesiumHCID 534008741-Iodooct-1-en-3-one

생성물 1

HCID 545226831-Iodo-3-methyloct-1-en-3-ol수율 86.9%

시약·촉매·용매 1

HCID 3283Diethyl Ether용매3회

실험 절차

To a Grignard solution prepared from 1.05 g (0.41 moles) of magnesium and 6.2 g (0.435 moles) of methyl iodide in 30 ml of dry ether under argon is added dropwise 10 g of 1-iodo-1-octen-3-one (Example 183) in 45 ml of ether. The resulting solution is stirred at ambient temperature for one hour. After the addition of 75 ml of saturated ammonium chloride the ether layer is separated and the aqueous layer is separated and the aqueous layer is extracted several times with ether. The coombined ether extracts are washed successively with ammonium chloride and water, dried and taken to dryness to give 9.24 g of product as an oil; λ max 2.89, 3.23, 6.24 and 10.5.

후처리

  1. customis separated
  2. customthe aqueous layer is separated
  3. extractionthe aqueous layer is extracted several times with ether
  4. washThe coombined ether extracts are washed successively with ammonium chloride and water
  5. customdried

출처 및 근거

ORD 기록
ord-a5f3e247922144a7a1f0ae11003ffdae
출처 데이터셋
uspto-grants-1979_05
특허 번호
US04154959

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