Oxetane → 3-[N'-(3-Hydroxypropyl)-N'-methylamino]-N,N,N-trimethyl-1-propanaminium Bromide

HRID 263167

반응식

HRID 263167 반응식
[O:1]1[CH2:4][CH2:3][CH2:2]1.[Br-:5].[CH3:6][N+:7]([CH3:14])([CH3:13])[CH2:8][CH2:9][CH2:10][NH:11][CH3:12]>O>[Br-:5].[OH:1][CH2:2][CH2:3][CH2:4][N:11]([CH2:10][CH2:9][CH2:8][N+:7]([CH3:14])([CH3:13])[CH3:6])[CH3:12]

참가 물질

4

반응물 2

HCID 10423OxetaneHCID 21444211N,N,N-Trimethyl-3-(methylamino)propan-1-aminium bromide

생성물 1

HCID 233475683-[N'-(3-Hydroxypropyl)-N'-methylamino]-N,N,N-trimethyl-1-propanaminium Bromide

시약·촉매·용매 1

HCID 962Water용매

실험 절차

A mixture of 20 g. of oxetane (0.34 mole), 32.8 g. of N,N,N-trimethyl-[3-(methylamino)]-1-propanaminium bromide (0.156 mole) and 22 ml. water is heated in a sealed tube at 100° for 15 hours. The solution is evaporated in vacuo and the residue is dissolved in 50 ml. of acetonitrile and filtered. Upon evaporation the desired product crystallizes. The product may be recrystallized from acetonitrile.

후처리

  1. additionA mixture of 20 g
  2. customThe solution is evaporated in vacuo
  3. dissolutionthe residue is dissolved in 50 ml
  4. filtrationof acetonitrile and filtered
  5. customUpon evaporation the desired product
  6. customcrystallizes
  7. customThe product may be recrystallized from acetonitrile

출처 및 근거

ORD 기록
ord-f2c120316ee347cb8ea232a7c1248f59
출처 데이터셋
uspto-grants-1979_05
특허 번호
US04156693

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