1-Bromo-3-chloropropane → 3-[N'-(3-Chloropropyl)-N'-methylamino]-N,N,N-trimethyl-1-propanaminium Bromide

HRID 263169

반응식

HRID 263169 반응식
[Br-].[CH3:2][N+:3]([CH3:10])([CH3:9])[CH2:4][CH2:5][CH2:6][NH:7][CH3:8].[Br:11][CH2:12][CH2:13][CH2:14][Cl:15]>C(#N)C>[Br-:11].[Cl:15][CH2:14][CH2:13][CH2:12][N:7]([CH2:6][CH2:5][CH2:4][N+:3]([CH3:10])([CH3:9])[CH3:2])[CH3:8]

참가 물질

4

반응물 2

HCID 80061-Bromo-3-chloropropaneHCID 21444211N,N,N-Trimethyl-3-(methylamino)propan-1-aminium bromide

생성물 1

HCID 213163783-[N'-(3-Chloropropyl)-N'-methylamino]-N,N,N-trimethyl-1-propanaminium Bromide

시약·촉매·용매 1

HCID 6342Acetonitrile용매

실험 절차

To a stirred solution of 3.02 g. (14.3 mmoles) of N,N,N-trimethyl-[3-(methylamino)]-1-propanaminium bromide in 30 ml. of acetonitrile is added a solution of 2.25 g. (14.3 mmoles) of 3-bromo-1-chloropropane and the mixture is stirred at room temperature under nitrogen for 3.5 hours. The mixture is cooled in an ice-water bath and then the insoluble material is removed by filtration. The filtrate is evaporated and dried in vacuo and is extracted with chloroform. The chloroform extract is evaporated and dried to give 2.05 g. (100%) of oily product; NMR δ: 2.2 (3H, S, --NCH3); 3.43 (9H, S, --N+ (CH3)3).

후처리

  1. temperatureThe mixture is cooled in an ice-water bath
  2. customthe insoluble material is removed by filtration
  3. customThe filtrate is evaporated
  4. customdried in vacuo
  5. extractionis extracted with chloroform
  6. extractionThe chloroform extract
  7. customis evaporated
  8. customdried
  9. customto give 2.05 g

출처 및 근거

ORD 기록
ord-1f60abf9c5b0446b8b37346274887e16
출처 데이터셋
uspto-grants-1979_05
특허 번호
US04156693

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