Hydrochloric Acid → 4,5,6,7-Tetrahydro-7-oxobenzo[b]thiophen-4-amine hydrochloride

A mixture of (+)-N-(4,5,6,7-tetrahydro-7-oxobenzo[b]thien-4-yl)formamide (52.65 grams) in 525 ml. of 95% ethanol and 525 ml. of 2 N HCl is heated at reflux for two hours. The mixture is cooled, filtered through glass wool and the filtrate is evaporated to dryness. The dark solid is dissolved in 180 ml. of water and the insoluble material is collected by filtration. The filter cake is washed with 70 ml. of water and the combined solution containing the title compound is used in the next operation. A 3 ml. solution is evaporated to dryness and the residue is dissolved in 95% ethanol. The ethanol solution is decolorized with activated carbon and filtered. The filtrate is evaporated to dryness to afford 0.5 grams of the title compound, m.p. 212°-214° C. (dec.), [α]D26 =+13.56° (c, 0.59 in methanol).

1. temperatureat reflux for two hours
2. temperatureThe mixture is cooled
3. filtrationfiltered through glass wool
4. customthe filtrate is evaporated to dryness
5. dissolutionThe dark solid is dissolved in 180 ml
6. filtrationof water and the insoluble material is collected by filtration
7. washThe filter cake is washed with 70 ml
8. additionof water and the combined solution containing the title compound
9. customsolution is evaporated to dryness
10. dissolutionthe residue is dissolved in 95% ethanol
11. filtrationfiltered
12. customThe filtrate is evaporated to dryness

ORD 기록

ord-5ac22b3d044a42fc9cc798c165f4ebab

출처 데이터셋

uspto-grants-1979_05

DOI

10.6084/m9.figshare.5104873.v1

특허 번호

US04156670