(1-Isopropylpiperidin-4-yl)methanamine → 2-Chloropropane

HRID 263217

반응식

HRID 263217 반응식
[Cl:1][C:2]1[CH:3]=C(SCl)[C:5]([C:8](Cl)=[O:9])=C[CH:7]=1.C([N:16]1[CH2:21][CH2:20][CH:19]([CH2:22][NH2:23])[CH2:18][CH2:17]1)(C)C>>[C:8]([NH:23][CH2:22][CH:19]1[CH2:18][CH2:17][NH:16][CH2:21][CH2:20]1)(=[O:9])[CH3:5].[CH:2]([Cl:1])([CH3:3])[CH3:7]

참가 물질

4

반응물 2

HCID 7258859(1-Isopropylpiperidin-4-yl)methanamineHCID 10728826HCID 10728826, 화합물

생성물 2

HCID 63612-ChloropropaneHCID 4341747N-(piperidin-4-ylmethyl)acetamide

실험 절차

2-(1-sopropylpiperid-4-ylmethyl)-6-chloro-1,2-benzisothiazolin-3-one is obtained analogously to Example 33 by reacting 3-chloro-6-chlorocarbonylphenylsulfenyl chloride and 1-isopropyl-4-aminomethylpiperidine [boiling point 15 :95°-97° C.; obtained from 4-acetylaminomethylpiperidine and isopropyl chloride analogously to Singh et al., J. Med. Chem. 12, 949 (1969) and Werbel et al., supra]. After recrystallization in acetone, yellow crystals of melting point 134°-135° C. are obtained; yield: 37% of theory.

후처리

  1. custom95°-97° C.

출처 및 근거

ORD 기록
ord-96feb2b4c82e4f69ac86803b109e0cef
출처 데이터셋
uspto-grants-1979_05
특허 번호
US04156729

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