Methanol → (3-Methoxypyridin-2-yl)methanol
반응식
[BH4-].[Na+].[CH3:3][O:4][C:5]1[C:6]([C:11](OC)=[O:12])=[N:7][CH:8]=[CH:9][CH:10]=1.CO>C(O)C>[OH:12][CH2:11][C:6]1[C:5]([O:4][CH3:3])=[CH:10][CH:9]=[CH:8][N:7]=1참가 물질
5
실험 절차
Sodium borohydride (6.3 g) was added slowly over 75 minutes to a solution of 3-methoxy-2-methoxycarbonylpyridine (9.2 g) in ethanol. Methanol (100 ml) was then added and after the initial vigorous reaction had subsided, further sodium borohydride (8.3 g) was added over a further 3 hours, and the mixture was left to stand overnight. The solvent was evaporated, the residue dissolved in water and extracted with chloroform and the chloroform solution dried. Evaporation, and crystallisation from ether gave 2-hydroxymethyl-3-methoxypyridine (4.4 g) m.p. 72.5°-73.5°.
후처리
- customafter the initial vigorous reaction
- waitthe mixture was left
- customThe solvent was evaporated
- dissolutionthe residue dissolved in water
- extractionextracted with chloroform
- dry with materialthe chloroform solution dried
- customEvaporation, and crystallisation from ether
출처 및 근거
- ORD 기록
- ord-d9439c4128894b84b47ff4f269566fc6
- 출처 데이터셋
- uspto-grants-1979_05
- 특허 번호
- US04156727
반응 노트
불러오는 중…