tert-Butyl isocyanate → N-(1-cyanoethyl)-N'-(1,1-dimethylethyl)urea

HRID 263265

반응식

HRID 263265 반응식
[NH2:1][CH:2]([CH3:5])[C:3]#[N:4].[C:6]([N:10]=[C:11]=[O:12])([CH3:9])([CH3:8])[CH3:7]>O1CCCC1>[C:3]([CH:2]([NH:1][C:11]([NH:10][C:6]([CH3:9])([CH3:8])[CH3:7])=[O:12])[CH3:5])#[N:4]

참가 물질

4

반응물 2

HCID 62412tert-Butyl isocyanateHCID 411840Propanenitrile, 2-amino-

생성물 1

HCID 21316847N-(1-cyanoethyl)-N'-(1,1-dimethylethyl)urea

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

To a stirring solution of 21.1 g (0.3 mole) 2-aminopropionitrile in 300 ml. dry tetrahydrofuran under a nitrogen atmosphere, there is added 30.7 g (0.3 mole) t-butyl isocyanate (97%). The resulting mixture is heated at reflux for five hours. At the end of this period, the tetrahydrofuran is removed at reduced pressure. The solid is recrystallized from methanol:water, 60:40, to give N-(1-cyanoethyl)-N'-(1,1-dimethylethyl)urea, m.p. 161°-3°.

후처리

  1. temperatureThe resulting mixture is heated
  2. temperatureat reflux for five hours
  3. customAt the end of this period, the tetrahydrofuran is removed at reduced pressure
  4. customThe solid is recrystallized from methanol

출처 및 근거

ORD 기록
ord-f6408094509d48d58ea659d4a8ff15bc
출처 데이터셋
uspto-grants-1979_05
특허 번호
US04156738

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