Hydrochloric Acid → HCID 19038100, 화합물

HRID 263457노트

반응식

HRID 263457 반응식
[Cl:1][C:2]1[C:3]([O:13][CH:14]2[CH:19]3[CH2:20][CH2:21][N:16]([CH2:17][CH2:18]3)[CH2:15]2)=[N:4][O:5][C:6]=1[C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=1.Cl>C(O)C.O1CCOCC1>[ClH:1].[Cl:1][C:2]1[C:3]([O:13][CH:14]2[CH:19]3[CH2:20][CH2:21][N:16]([CH2:17][CH2:18]3)[CH2:15]2)=[N:4][O:5][C:6]=1[C:7]1[CH:8]=[CH:9][CH:10]=[CH:11][CH:12]=1

참가 물질

5

반응물 2

HCID 313Hydrochloric AcidHCID 19038078HCID 19038078, 화합물

생성물 1

HCID 19038100HCID 19038100, 화합물수율 198%

시약·촉매·용매 2

HCID 702Ethanol용매HCID 312751,4-Dioxane용매

실험 절차

A solution of 2.12 g of 4-chloro-3-(3-quinuclidinyloxy)-5-phenylisoxazole (prepared as described in Example 9) in 20 ml of ethanol was cooled to 5° C. 2.1 ml of a 4N solution of hydrogen chloride in dioxane were then added dropwise to the solution, and the resulting mixture was stirred at room temperature for 30 minutes. At the end of this time, the reaction mixture was concentrated by distillation under reduced pressure and the solid residue thus obtained was recrystallized from ethanol to afford 2.35 g (yield 96.1%) of the title compound as a colorless powder, melting at 235°-237° C. (with decomposition).

후처리

  1. concentrationAt the end of this time, the reaction mixture was concentrated by distillation under reduced pressure
  2. customthe solid residue thus obtained
  3. customwas recrystallized from ethanol

출처 및 근거

ORD 기록
ord-ce77b1584baa49bebc9421e59846f3e6
출처 데이터셋
uspto-grants-1997_07
특허 번호
US05643923

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