2',4'-Dihydroxyacetophenone → 1-[4-(3-Chloropropoxy)-2-hydroxyphenyl]-1-ethanone
반응식
[OH:1][C:2]1[CH:7]=[C:6]([OH:8])[CH:5]=[CH:4][C:3]=1[C:9](=[O:11])[CH3:10].Br[CH2:13][CH2:14][CH2:15][Cl:16].C(=O)([O-])[O-].[K+].[K+]>CC(C)=O>[Cl:16][CH2:15][CH2:14][CH2:13][O:8][C:6]1[CH:5]=[CH:4][C:3]([C:9](=[O:11])[CH3:10])=[C:2]([OH:1])[CH:7]=1참가 물질
5
실험 절차
10 g (66 mmole) of 2',4'-dihydroxyacetophenone, 10 ml (101 mmole) of 1-bromo-3-chloropropane and 22.7 g (164 mmole) of anhydrous potassium carbonate in 250 ml of acetone were mixed and refluxed under heating for 16 hours. The mixture was cooled to room temperature, the solid insoluble was separated by filtration, and the filtrate was evaporated to dryness. The residue was dispersed in ethyl ether, filtered and dried to give 13.1 g (87%) of the product, melting point 74° C.
후처리
- temperaturerefluxed
- temperatureunder heating for 16 hours
- customthe solid insoluble was separated by filtration
- customthe filtrate was evaporated to dryness
- additionThe residue was dispersed in ethyl ether
- filtrationfiltered
- customdried
출처 및 근거
- ORD 기록
- ord-6ddbaf6bf6ee49f2989f825a5856d3a5
- 출처 데이터셋
- uspto-grants-1997_07
- 특허 번호
- US05643927
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