2',4'-Dihydroxyacetophenone → 1-[4-(3-Chloropropoxy)-2-hydroxyphenyl]-1-ethanone

HRID 263463

반응식

HRID 263463 반응식
[OH:1][C:2]1[CH:7]=[C:6]([OH:8])[CH:5]=[CH:4][C:3]=1[C:9](=[O:11])[CH3:10].Br[CH2:13][CH2:14][CH2:15][Cl:16].C(=O)([O-])[O-].[K+].[K+]>CC(C)=O>[Cl:16][CH2:15][CH2:14][CH2:13][O:8][C:6]1[CH:5]=[CH:4][C:3]([C:9](=[O:11])[CH3:10])=[C:2]([OH:1])[CH:7]=1

참가 물질

5

반응물 3

HCID 69902',4'-DihydroxyacetophenoneHCID 80061-Bromo-3-chloropropaneHCID 11430Potassium Carbonate

생성물 1

HCID 17146611-[4-(3-Chloropropoxy)-2-hydroxyphenyl]-1-ethanone수율 87%

시약·촉매·용매 1

HCID 180Acetone용매

실험 절차

10 g (66 mmole) of 2',4'-dihydroxyacetophenone, 10 ml (101 mmole) of 1-bromo-3-chloropropane and 22.7 g (164 mmole) of anhydrous potassium carbonate in 250 ml of acetone were mixed and refluxed under heating for 16 hours. The mixture was cooled to room temperature, the solid insoluble was separated by filtration, and the filtrate was evaporated to dryness. The residue was dispersed in ethyl ether, filtered and dried to give 13.1 g (87%) of the product, melting point 74° C.

후처리

  1. temperaturerefluxed
  2. temperatureunder heating for 16 hours
  3. customthe solid insoluble was separated by filtration
  4. customthe filtrate was evaporated to dryness
  5. additionThe residue was dispersed in ethyl ether
  6. filtrationfiltered
  7. customdried

출처 및 근거

ORD 기록
ord-6ddbaf6bf6ee49f2989f825a5856d3a5
출처 데이터셋
uspto-grants-1997_07
특허 번호
US05643927

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