Boc-Asp(O-cHex) Man(4-MBzl) → Asp(O-cHex) Man(4-MBzl)

HRID 263498

반응식

HRID 263498 반응식
[NH:1](C(OC(C)(C)C)=O)[C@H:2]([C:13]([OH:15])=[O:14])[CH2:3][C:4](=[O:12])[O:5][CH:6]1[CH2:11][CH2:10][CH2:9][CH2:8][CH2:7]1.[OH:23][CH:24]1[O:40][C@H:39]([CH2:41][OH:42])[C@@H:29]([O:30][CH2:31][C:32]2[CH:38]=[CH:37][C:35]([CH3:36])=[CH:34][CH:33]=2)[C@H:27]([OH:28])[C@@H:25]1[OH:26]>C(O)(C(F)(F)F)=O.C(Cl)Cl>[NH2:1][C@H:2]([C:13]([OH:15])=[O:14])[CH2:3][C:4](=[O:12])[O:5][CH:6]1[CH2:11][CH2:10][CH2:9][CH2:8][CH2:7]1.[OH:23][CH:24]1[O:40][C@H:39]([CH2:41][OH:42])[C@@H:29]([O:30][CH2:31][C:32]2[CH:38]=[CH:37][C:35]([CH3:36])=[CH:34][CH:33]=2)[C@H:27]([OH:28])[C@@H:25]1[OH:26]

참가 물질

3

반응물 1

HCID 131720065Boc-Asp(O-cHex) Man(4-MBzl)

생성물 1

HCID 131720066Asp(O-cHex) Man(4-MBzl)수율 107.8%

시약·촉매·용매 1

HCID 21863450Trifluoroacetic acid methylene chloride용매

실험 절차

Boc-Asp(O-cHex)-Man(4-MBzl) (52 g) was treated with 50% TFA/methylene chloride (400 mL) for 45 min at room temperature. The solvent was evaporated and chased several times with methylene chloride to eliminate traces of TFA. The product precipitated as its TFA salt upon addition of ether. The solid was collected and air dried to yield a white solid (46.7 g, 88%).

후처리

  1. customThe solvent was evaporated
  2. customThe product precipitated as its TFA salt upon addition of ether
  3. customThe solid was collected
  4. customair dried

출처 및 근거

ORD 기록
ord-ce3cf141d3b541f7b31680b4023b0da8
출처 데이터셋
uspto-grants-1997_07
특허 번호
US05643872

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