1,4-Bis[4-[(1-benzyloxyureido)methyl]phenoxy]butane → 1,4-Bis[4-[(1-hydroxyureido)methyl]phenoxy]butane

HRID 263537

반응식

HRID 263537 반응식
C([O:8][N:9]([CH2:13][C:14]1[CH:44]=[CH:43][C:17]([O:18][CH2:19][CH2:20][CH2:21][CH2:22][O:23][C:24]2[CH:29]=[CH:28][C:27]([CH2:30][N:31]([O:35]CC3C=CC=CC=3)[C:32]([NH2:34])=[O:33])=[CH:26][CH:25]=2)=[CH:16][CH:15]=1)[C:10]([NH2:12])=[O:11])C1C=CC=CC=1.[H][H]>CN(C)C=O.C(O)C.[C].[Pd]>[OH:35][N:31]([CH2:30][C:27]1[CH:28]=[CH:29][C:24]([O:23][CH2:22][CH2:21][CH2:20][CH2:19][O:18][C:17]2[CH:43]=[CH:44][C:14]([CH2:13][N:9]([OH:8])[C:10]([NH2:12])=[O:11])=[CH:15][CH:16]=2)=[CH:25][CH:26]=1)[C:32]([NH2:34])=[O:33]

참가 물질

5

반응물 2

HCID 542130111,4-Bis[4-[(1-benzyloxyureido)methyl]phenoxy]butaneHCID 178418361HCID 178418361, 화합물

생성물 1

HCID 542604191,4-Bis[4-[(1-hydroxyureido)methyl]phenoxy]butane수율 62%

시약·촉매·용매 2

HCID 178418390HCID 178418390, 화합물촉매HCID 19794673N,N-dimethylformamide ethanol용매

실험 절차

1,4-Bis[4-[(1-benzyloxyureido)methyl]phenoxy]butane (1.94 g) was dissolved in 45 ml of dimethylformamide-ethanol (8:1), mixed with 0.29 g of 10% palladium carbon and then the mixture was stirred for 22 hours at room temperature in an atmosphere of hydrogen. The catalyst was removed by filtration using Celite, and the solvent was evaporated under a reduced pressure to obtain 0.84 g of 1,4-bis[4-[(1-hydroxyureido)methyl]phenoxy]butane.

후처리

  1. customThe catalyst was removed by filtration
  2. customthe solvent was evaporated under a reduced pressure

출처 및 근거

ORD 기록
ord-0864f6c93e4148b1b8946b1cc0b66e5f
출처 데이터셋
uspto-grants-1997_07
특허 번호
US05643931

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