1,3-Dichloroacetone → 4-(Chloromethyl)-2-(3,4-dimethoxyphenyl)-1,3-thiazole
반응식
[Cl:1][CH2:2][C:3]([CH2:5]Cl)=O.[CH3:7][O:8][C:9]1[CH:10]=[C:11]([CH:15]=[CH:16][C:17]=1[O:18][CH3:19])[C:12]([NH2:14])=[S:13]>C(O)C>[CH3:7][O:8][C:9]1[CH:10]=[C:11]([C:12]2[S:13][CH:5]=[C:3]([CH2:2][Cl:1])[N:14]=2)[CH:15]=[CH:16][C:17]=1[O:18][CH3:19]참가 물질
4
실험 절차
1.5 g of 1,3-dichloroacetone and 2.3 g of 3,4-dimethoxythiobenzamide were suspended in 100 ml of ethanol. The suspension was heated for 3 hours to complete the reaction. The solvent was removed by distillation. The residue was purified by silica gel column chromatography to obtain 1.86 g of 2-(3,4-dimethoxyphenyl)-4-chloromethylthiazole as a colorless viscous oil.
후처리
- temperatureThe suspension was heated for 3 hours
- customthe reaction
- customThe solvent was removed by distillation
- customThe residue was purified by silica gel column chromatography
출처 및 근거
- ORD 기록
- ord-19dcf3fcf65d4c3c8331b4824556e40d
- 출처 데이터셋
- uspto-grants-1997_07
- 특허 번호
- US05643932
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