Nitric Acid → 8-Chloro-2-methyl-5-nitroquinoline

HRID 26363

반응식

HRID 26363 반응식
[Cl:1][C:2]1[CH:3]=[CH:4][CH:5]=[C:6]2[C:11]=1[N:10]=[C:9]([CH3:12])[CH:8]=[CH:7]2.[N+:13]([O-])([OH:15])=[O:14].[OH-].[Na+]>S(=O)(=O)(O)O>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([N+:13]([O-:15])=[O:14])=[C:6]2[C:11]=1[N:10]=[C:9]([CH3:12])[CH:8]=[CH:7]2

참가 물질

5

반응물 3

HCID 944Nitric AcidHCID 14798Sodium HydroxideHCID 2211138-Chloro-2-methylquinoline

생성물 1

HCID 177506238-Chloro-2-methyl-5-nitroquinoline수율 96.7%

시약·촉매·용매 1

HCID 1118Sulfuric Acid용매

실험 절차

53.3 g (0.3 mole) of the resulting 8-chloroquinaldine was dissolved in 180.2 g of 98% sulfuric acid, and at 40° C., 40.2 g of nitric acid (specific gravity 1.50) was added dropwise over the course of 1 hour, followed by further reaction for 30 minutes. The reaction mixture was poured into ice water, and neutralized with an aqueous solution of sodium hydroxide. The product precipitated was collected by filtration, washed with water, and dried to afford 64.1 g (0.29 mole) of 8-chloro-5-nitroquinaldine.

후처리

  1. customfollowed by further reaction for 30 minutes
  2. customThe product precipitated
  3. filtrationwas collected by filtration
  4. washwashed with water
  5. customdried

출처 및 근거

ORD 기록
ord-20462d786d2d4e94adfd61fbc12d4b76
출처 데이터셋
uspto-grants-1979_04
특허 번호
US04150025

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